Blood pressure and cognitive decline in healthy old people

Age-associated cognitive decline in healthy old people.

BACKGROUND disease often confounds the identification of risk factors for age-associated cognitive decline in elderly subjects. If the cognitive effects of ageing are to be distinguished from those of disease, healthy people need to be studied. METHODS we examined the effects of incident disease and drug prescription on cognitive change in a sample of initially healthy old people in a longitu...

Blood pressure and mortality in healthy old people: the r shaped curve.

Current and remote blood pressure and cognitive decline.

CONTEXT Previous studies raise the possibility that blood pressure (BP) in middle age predicts later cognitive decline. OBJECTIVE To examine prospectively the relationship of BP with level of and change in cognitive function in the elderly. DESIGN Longitudinal, population-based study comprising subjects enrolled in the East Boston component of the Established Populations for the Epidemiolog...

Blood pressure variability predicts cognitive decline in Alzheimer's disease patients.

The aim of our study was to evaluate whether blood pressure variability influences the rate of cognitive decline in Alzheimer's disease (AD). Two hundred and forty AD patients were periodically evaluated for a 12-month period. The blood pressure (BP) status of each patient was defined through mean and coefficient of variation for both systolic and diastolic BP. Progression of cognitive decline ...

Blood pressure-related cognitive decline: does age make a difference?

Systolic and diastolic blood pressures have been inversely related to cognitive performance in prospective and cross-sectional studies. However, in large, community-based samples, these findings have been limited to older adults. In this 20-year longitudinal study, we examined the relationship between baseline blood pressure and cognitive decline for 529 participants using 2 age groups (18 to 4...